|Georgemr||Дата: Вт, 26.08.2014, 17:50 | Сообщение # 1|
|Patients treated with both dosing regimens of ixekizumab had significantly greater levels of film clearance compared to placebo and to etanercept at the 12-week endpoint. Peel leeway was measured via standard essential endpoints looking for psoriasis studies: the Psoriasis Square footage and Inhumanity Directory (PASI) and the Unchanged Physician Global Assessment (sPGA). |
On patients treated with ixekizumab either every four weeks or every two weeks, between 78 to 90 percent of patients achieved at least a 75 percent reduction in PASI accompaniment (PASI 75) at 12 weeks. Additionally, 31 to 41 percent of these patients achieved PASI 100, or unmistakable bark, at week 12. An eye to commensurability, between 5 to 7 percent of patients treated with etanercept in the UNCOVER-2 and 3 studies achieved PASI 100.
Statistically consequential improvements in pellicle clearance measures after patients treated with ixekizumab were observed as inopportune as the beginning week when compared to either placebo or etanercept, and continued in the course week 12. In the UNCOVER-1 ruminate on, stiff levels of response were maintained through 60 weeks of treatment.
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